“Preventing Suicide among Sexual and Gender Diverse Youth” aims to inform clinical practices on reducing suicidal thoughts and behaviors among sexual and gender diverse young adults (SGDYA). Specifically, the study uses a cluster randomized design to compare the effectiveness of two brief suicide interventions in a trial involving 598 SGDYA seeking care in primary health clinics across Texas. The first intervention utilizes motivational interviewing (MI) to enhance problem-solving skills and facilitate access to mental health services. The second intervention involves linking youth with mental health resources and establishing a support team of adults to offer encouragement and guidance towards seeking help. Emphasizing inclusivity, both interventions have been adapted with feedback from diverse community stakeholders and youth with lived experience. Participants are surveyed over a year to measure the interventions’ effectiveness on suicidal ideation, mental health service utilization, suicide attempts, depression, and social support.